卡比多巴单水合物

卡比多巴单水合物化学性质

储存条件 :Keep in dark place,Inert atmosphere,Room temperature
溶解度 :Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
形态 :Solid
颜色 :White to Off-White
CAS 数据库 :38821-49-7(CAS DataBase Reference)

安全信息

WGK Germany :3
RTECS号 :MW5300000
危险等级 :IRRITANT
海关编码 :2928002500
毒性 :mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.

卡比多巴单水合物化学药品说明书

卡比多巴|药典2005版
卡比多巴片|药典2005版

用途卡比多巴为类白色绒毛状结晶；几乎无臭。与左旋多巴联合应用，用于帕金森病和帕金森综合征。
生物活性 Carbidopa ((S)-(-)-Carbidopa) monohydrate 是一种外周型脱羧酶 (decarboxylase) 抑制剂，可用于帕金森病的研究。Carbidopa monohydrate 是一种选择性芳香烃受体 (AhR) 调节剂。Carbidopa monohydrate 抑制胰腺癌细胞和肿瘤生长。
体外研究

Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191.
Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC ₅₀ =29 μM).
体内研究

Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts.
类别有毒物质
毒性分级中毒
急性毒性口服-大鼠 LD50: 4810 毫克/公斤; 口服-小鼠 LD50: 1750 毫克/公斤
可燃性危险特性热分解排出有毒氮氧化物烟雾
储运特性库房低温通风干燥
灭火剂水, 二氧化碳, 泡沫, 干粉

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