ChemicalBook CAS数据库列表 抑二肽素A
抑二肽素A
- CAS号:90614-48-5
- 英文名:DIPROTIN A
- 中文名:抑二肽素A
- CBNumber:CB6261540
- 分子式:C17H31N3O4
- 分子量:341.45
- MOL File:90614-48-5.mol
抑二肽素A化学性质
- 沸点 :583.1±50.0 °C(Predicted)
- 密度 :1.140±0.06 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :DMSO:250.0(Max Conc. mg/mL);732.17(Max Conc. mM)
Water:67.08(Max Conc. mg/mL);196.44(Max Conc. mM) - 形态 :White to off-white solid.
- 酸度系数(pKa) :3.72±0.22(Predicted)
- 颜色 :White to off-white
- 水溶解性 :Soluble in water at 1mg/ml
- CAS 数据库 :90614-48-5(CAS DataBase Reference)
安全信息
- WGK Germany :3
- RTECS号 :NR4737000
抑二肽素A性质、用途与生产工艺
- 生物活性 Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
-
靶点
IC50: DPP-IV
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体外研究
Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor.
Western Blot Analysis
Cell Line: Human endothelial cells [1] Concentration: 100 μM Incubation Time: 30 minutes after CXCR4-blocker or Src-inhibitor treatment Result: Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs. -
体内研究
Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
Animal Model: Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice Dosage: 70 μg/kg Administration: Intraperitoneal injection; twice daily; 7 days Result: Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
抑二肽素A上下游产品信息
上游原料
下游产品
抑二肽素A 试剂级价格
- 更新日期：2024/11/11
- 产品编号：XW9061448503
- 产品名称：试剂Diprotin A Diprotin A
- CAS编号：
- 包装：100mg
- 价格：5478元
- 更新日期：2024/11/11
- 产品编号：XW9061448502
- 产品名称：试剂Diprotin A Diprotin A
- CAS编号：
- 包装：25mg
- 价格：1870元
抑二肽素A生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
- 公司名称：ALEXIS
- 联系电话：--
- 电子邮件：alexis-ch@alexis-corp.ch
- 国家：瑞士
- 产品数：3599
- 优势度：74
- 公司名称：SENNCHEM
- 联系电话：--
- 电子邮件：swiss@sennchem.com
- 国家：瑞士
- 产品数：3143
- 优势度：71
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