生物活性 靶点 体外研究 体内研究 抑二肽素A 试剂级价格
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抑二肽素A

抑二肽素A,90614-48-5,结构式
抑二肽素A
  • CAS号:90614-48-5
  • 英文名:DIPROTIN A
  • 中文名:抑二肽素A
  • CBNumber:CB6261540
  • 分子式:C17H31N3O4
  • 分子量:341.45
  • MOL File:90614-48-5.mol
抑二肽素A化学性质
  • 沸点 :583.1±50.0 °C(Predicted)
  • 密度 :1.140±0.06 g/cm3(Predicted)
  • 储存条件 :-20°C
  • 溶解度 :DMSO:250.0(Max Conc. mg/mL);732.17(Max Conc. mM)
    Water:67.08(Max Conc. mg/mL);196.44(Max Conc. mM)
  • 形态 :White to off-white solid.
  • 酸度系数(pKa) :3.72±0.22(Predicted)
  • 颜色 :White to off-white
  • 水溶解性 :Soluble in water at 1mg/ml
  • CAS 数据库 :90614-48-5(CAS DataBase Reference)
安全信息
  • WGK Germany :3
  • RTECS号 :NR4737000

抑二肽素A性质、用途与生产工艺

  • 生物活性 Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
  • 靶点

    IC50: DPP-IV

  • 体外研究

    Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor.

    Western Blot Analysis

    Cell Line: Human endothelial cells [1]
    Concentration: 100 μM
    Incubation Time: 30 minutes after CXCR4-blocker or Src-inhibitor treatment
    Result: Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs.
  • 体内研究

    Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.

    Animal Model: Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice
    Dosage: 70 μg/kg
    Administration: Intraperitoneal injection; twice daily; 7 days
    Result: Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
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抑二肽素A 试剂级价格
  • 更新日期:2024/11/11
  • 产品编号:XW9061448503
  • 产品名称:试剂Diprotin A Diprotin A
  • CAS编号:
  • 包装:100mg
  • 价格:5478元
  • 更新日期:2024/11/11
  • 产品编号:XW9061448502
  • 产品名称:试剂Diprotin A Diprotin A
  • CAS编号:
  • 包装:25mg
  • 价格:1870元
抑二肽素A生产厂家
  • 公司名称:PEPTIDE-INST
  • 联系电话:--
  • 电子邮件:info@peptide.co.jp
  • 国家:日本
  • 产品数:992
  • 优势度:70
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