硝酸异康唑

硝酸异康唑化学性质

熔点 :178-182°C
储存条件 :Sealed in dry,2-8°C
溶解度 :Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).
形态 :Solid
颜色 :White to Off-White
Merck :14,5160
CAS 数据库 :24168-96-5(CAS DataBase Reference)

安全信息

硝酸异康唑性质、用途与生产工艺

概述硝酸异康唑是一种具有广谱抗真菌作用的咪唑类抗真菌药，对白色念珠菌、表皮癣菌及某些革兰阳性菌均有抑制作用。硝酸异康唑于1979年在法国上市，因其具有疗效显著，毒副作用低等优点，具有广阔的市场前景。
生物活性 Isoconazole nitrate 是一种唑类抗真菌药物。
体外研究

Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure.
Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells.
用途属广谱抗真菌药

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硝酸异康唑试剂级价格

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