ChemicalBook CAS数据库列表 多佐胺
多佐胺
- CAS号:120279-96-1
- 英文名:Dorzolamide
- 中文名:多佐胺
- CBNumber:CB4174657
- 分子式:C10H16N2O4S3
- 分子量:324.44
- MOL File:120279-96-1.mol
多佐胺化学性质
- 沸点 :575.8±60.0 °C(Predicted)
- 密度 :1.53±0.1 g/cm3(Predicted)
- 储存条件 :room temp
- 溶解度 :DMSO: soluble5mg/mL (clear solution, warmed)
- 酸度系数(pKa) :pKa 6.35 (Uncertain);8.50 (Uncertain)
- 形态 :powder
- 颜色 :white to beige
- 旋光性 (optical activity) :[α]/D -25 to -35°, c = 1 in methanol
- CAS 数据库 :120279-96-1(CAS DataBase Reference)
安全信息
多佐胺性质、用途与生产工艺
- 生物活性 Dorzolamide (L671152) 是有效的碳酸酐酶 carbonic anhydrase II 的抑制剂，其对红细胞 CA-II 和 CA-I 的 IC50 值分别为 0.18 nM 和 600 nM。
-
体外研究
Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC 50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM).
-
体内研究
Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively).
Animal Model: Female Swiss albino mice (EAC solid tumor). Dosage: 3, 10, or 30 mg/kg/day (synergized mitomycin C). Administration: IP, daily for 3 weeks. Result: Upregulated TXNIP and p53 while downregulated bcl-2.
Effective in retarding the growth of EAC in mice.
多佐胺上下游产品信息
上游原料
下游产品
多佐胺生产厂家
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
120279-96-1, 多佐胺相关搜索:
