ChemicalBook CAS数据库列表 兰雪醌
兰雪醌
- CAS号:481-42-5
- 英文名:PLUMBAGIN
- 中文名:兰雪醌
- CBNumber:CB4144779
- 分子式:C11H8O3
- 分子量:188.18
- MOL File:481-42-5.mol
兰雪醌化学性质
- 熔点 :76-78 °C(lit.)
- 沸点 :283.17°C (rough estimate)
- 密度 :1.354
- 折射率 :1.6310 (estimate)
- 储存条件 :-20°C
- 溶解度 :very faint turbidity in hot Methanol
- 形态 :Crystals or Crystalline Powder
- 酸度系数(pKa) :6.70±0.20(Predicted)
- 颜色 :Orange
- Merck :7538
- 稳定性 :Hygroscopic
- LogP :2.450 (est)
- EPA化学物质信息 :1,4-Naphthalenedione, 5-hydroxy-2-methyl- (481-42-5)
安全信息
- 危险品标志 :T
- 危险类别码 :25-34-36/37/38
- 安全说明 :22-26-36/37/39-45-37/39-28A
- 危险品运输编号 :UN 2923 8/PG 2
- WGK Germany :3
- RTECS号 :QL8500000
- Hazard Note :Toxic
- 危险等级 :6.1(a)
- 包装类别 :II
- 海关编码 :29146990
- 毒性 :LD50 i.p. in mice: ~0.015 g/kg (Debray)
兰雪醌性质、用途与生产工艺
- 生物活性 Plumbagin (2-Methyljuglone) 是从 Plumbago zeylanica L 中得到的萘醌类物质，具有抗肿瘤、抗增殖活性。
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体外研究
Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner.
Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells.Apoptosis Analysis
Cell Line: DU145, CWR22rv1, LNCaP and RWPE-1 cells Concentration: 0, 5, 10, and 15 μM Incubation Time: 24 hours Result: Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM. -
体内研究
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice.
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice.Animal Model: Male athymic nude mice bearing DU145 cells Dosage: 2 mg/kg Administration: I.P. after 3 days post cell implantation, five days a week. Result: Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice. - 用途 用作染料中间体，用于生产26紫、28紫、双氰等
兰雪醌上下游产品信息
上游原料
下游产品
兰雪醌 试剂级价格
- 更新日期：2024/11/11
- 产品编号：XW48142501
- 产品名称：兰雪醌
- CAS编号：
- 包装：250mg
- 价格：539元
- 更新日期：2024/11/08
- 产品编号：18404
- 产品名称：兰雪醌 Plumbagin, 99+%, Thermo Scientific Chemicals
- CAS编号：481-42-5
- 包装：1g
- 价格：2192元
兰雪醌生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
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