ICI 118,551 HYDROCHLORIDE
- CAS号:72795-01-8
- 英文名:(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
- 中文名:ICI 118,551 HYDROCHLORIDE
- CBNumber:CB32518939
- 分子式:C17H28ClNO2
- 分子量:313.87
- MOL File:72795-01-8.mol
- 储存条件 :desiccated
- 溶解度 :DMSO : 25 mg/mL (79.65 mM; Need ultrasonic)H2O : 12.5 mg/mL (39.83 mM; Need ultrasonic)
- 形态 :powder
- 颜色 :white
- WGK Germany :3
ICI 118,551 HYDROCHLORIDE性质、用途与生产工艺
- 生物活性 ICI 118,551 hydrochloride 是一种高度选择性的 β2 adrenergic receptor 拮抗剂，结合 β2，β1 和 β3 肾上腺素能受体的Ki 值分别为 0.7，49.5 和 611 nM。
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靶点
Ki: 0.7nM (β2 receptor), 49.5 nM (β1 receptor), 611 nM (β3 receptor)
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体外研究
ICI 118551 inhibits cAMP accumulation with IC 50 of 1.7 μM in IMCD cells. ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO. In failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of ICI 118551.
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体内研究
ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.
- 更新日期：2024/11/08
- 产品编号：S8114
- 产品名称：ICI 118,551 HYDROCHLORIDE ICI-118551 Hydrochloride
- CAS编号：72795-01-8
- 包装：5mg
- 价格：1613.61元
- 更新日期：2024/11/08
- 产品编号：S8114
- 产品名称：Zenidolol (ICI-118551) Hydrochloride
- CAS编号：72795-01-8
- 包装：10mM (1mL in DMSO)
- 价格：1875.51元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
