ICI 118,551 HYDROCHLORIDE
ICI 118,551 HYDROCHLORIDE
ICI 118,551 HYDROCHLORIDE 性质
| 储存条件 | desiccated |
|---|---|
| 溶解度 | DMSO : 25 mg/mL (79.65 mM; 需要超声波)H2O : 12.5 mg/mL (39.83 mM; 需要超声波) |
| 形态 | 粉末 |
| 颜色 | 白色 |
ICI 118,551 HYDROCHLORIDE 用途与合成方法
Ki: 0.7nM (β2 receptor), 49.5 nM (β1 receptor), 611 nM (β3 receptor)
ICI 118551 inhibits cAMP accumulation with IC 50 of 1.7 μM in IMCD cells. ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO. In failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of ICI 118551.
ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.
ICI 118,551 HYDROCHLORIDE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | S8114 | ICI 118,551 HYDROCHLORIDE | 72795-01-8 | 5mg | 1613.61 |
| 2024-11-08 | S8114 | 72795-01-8 | 10mM (1mL in DMSO) | 1875.51 |
