ChemicalBook CAS数据库列表 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮
![1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮,41443-28-1,结构式](https://www.chemicalbook.com/CAS/GIF/41443-28-1.gif)
- CAS号:41443-28-1
- 英文名:ODQ
- 中文名:1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮
- CBNumber:CB2730905
- 分子式:C9H5N3O2
- 分子量:187.15
- MOL File:41443-28-1.mol
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮化学性质
- 熔点 :160-170 °C
- 沸点 :321.89°C (rough estimate)
- 密度 :1.3753 (rough estimate)
- 折射率 :1.6500 (estimate)
- RTECS号 :RO0913150
- 储存条件 :2-8°C
- 溶解度 :ethanol: 1.2 mg/mL
- 形态 :powder
- 酸度系数(pKa) :0.94±0.20(Predicted)
- 颜色 :pale yellow
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- CAS 数据库 :41443-28-1(CAS DataBase Reference)
安全信息
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮性质、用途与生产工艺
- 生物活性 ODQ (1H-ODQ) 是一种有效的和选择性的 soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) 的抑制剂，可增强顺铂在人类间皮瘤细胞中的促凋亡作用。
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靶点
Target Value sGC
() -
体外研究
At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM.
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体内研究
ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat.
Animal Model: Anesthetized, male Wistar rats Dosage: 2 mg/kg Administration: I.p. Result: Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide.
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮上下游产品信息
上游原料
下游产品
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 试剂级价格
- 更新日期：2024/11/08
- 产品编号：32880
- 产品名称：1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 10MG ODQ, 98%, Thermo Scientific Chemicals
- CAS编号：41443-28-1
- 包装：10mg
- 价格：1826元
- 更新日期：2024/11/08
- 产品编号：32880
- 产品名称：1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 10MG ODQ, 98%, Thermo Scientific Chemicals
- CAS编号：41443-28-1
- 包装：50mg
- 价格：7226元
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮生产厂家
- 公司名称：TCI AMERICA
- 联系电话：800-4238616
- 电子邮件：sales@tciamerica.com
- 国家：美洲
- 产品数：23653
- 优势度：75
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