托美丁钠(二水)
- CAS号:64490-92-2
- 英文名:Sodium tolmetin dihydrate
- 中文名:托美丁钠(二水)
- CBNumber:CB2352833
- 分子式:C15H14NO3.Na.2H2O
- 分子量:315.3
- MOL File:64490-92-2.mol
- 熔点 :155-157 (dec.)
- 储存条件 :-20°C Freezer
- 溶解度 :Methanol (Slightly), Water (Slightly)
- 形态 :Solid
- 颜色 :White to Beige
- 水溶解性 :Soluble in water
- InChIKey :QQILXENAYPUNEA-UHFFFAOYSA-M
- CAS 数据库 :64490-92-2(CAS DataBase Reference)
托美丁钠(二水)性质、用途与生产工艺
- 生物活性 Tolmetin sodium dehydrate 是一种具有口服活性的，有效的 COX 抑制剂，对人 COX-1 和 COX-2 的 IC50 值分别为 0.35 µM 和 0.82 µM。Tolmetin sodium dehydrate 属于非甾体类物质，具有强效的抗炎活性。
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靶点
Human COX-1
0.35 μM (IC 50 )
Human COX-2
0.82 μM (IC 50 )
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体外研究
Tolmetin sodium dihydrate (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin sodium dihydrate (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin sodium dihydrate (0-100 μM) shows no effect on osteoblast growth.
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体内研究
Tolmetin sodium dihydrate (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin sodium dihydrate (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
- 更新日期：2024/11/08
- 产品编号：HY-B1489
- 产品名称：托美丁钠(二水) Tolmetin sodium dihydrate
- CAS编号：64490-92-2
- 包装：100mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-B1489
- 产品名称：托美丁钠(二水) Tolmetin sodium dihydrate
- CAS编号：64490-92-2
- 包装：10mM * 1mLin DMSO
- 价格：550元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
