奥西那林
- CAS号:586-06-1
- 英文名:Orciprenaline
- 中文名:奥西那林
- CBNumber:CB1855195
- 分子式:C11H17NO3
- 分子量:211.26
- MOL File:586-06-1.mol
- 熔点 :100°
- 沸点 :350.94°C (rough estimate)
- 密度 :1.1240 (rough estimate)
- 折射率 :1.5718 (estimate)
- 酸度系数(pKa) :9.11±0.10(Predicted)
- CAS 数据库 :586-06-1(CAS DataBase Reference)
奥西那林性质、用途与生产工艺
- 生物活性 Metaproterenol (Orciprenaline) 是一种直接作用的拟交感神经药，是 β2-肾上腺素能受体 (β2AR) 激动剂，其 IC50 为 68 nM。Metaproterenol 还具有抗炎活性。
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靶点
IC50: 68 nM (β2-adrenergic receptor)
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体外研究
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.Western Blot Analysis
Cell Line: THP-1 cells and bone marrow macrophages Concentration: 10 μM Incubation Time: 74 hours Result: Enhanced β-arrestin2 and its interaction with IκBα. RT-PCR
Cell Line: THP-1 cells and bone marrow macrophages Concentration: 10 μM Incubation Time: 74 hours Result: Led to downregulation of NF-κB. -
体内研究
Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
- 化学性质 熔点100℃。其硫酸（[5874-97-5]）熔点202-203℃。
- 用途 支气管扩张药。
- 生产方法 3，5-二乙酸基乙酰首先与溴反应，然后与异丙胺反应得过且过-（3，5-二羟基苯基）-2-异丙胺乙酮，将其溶于甲醇，在室温下以镍催化氢化，得异丙喘宁。
- 公司名称：Leancare Ltd.
- 联系电话：--
- 电子邮件：enquiry@leancare.co.uk
- 国家：英国
- 产品数：6446
- 优势度：42
