ChemicalBook CAS数据库列表 山竹子素
山竹子素
- CAS号:78824-30-3
- 英文名:garcinol
- 中文名:山竹子素
- CBNumber:CB11347121
- 分子式:C38H50O6
- 分子量:602.8
- MOL File:78824-30-3.mol
山竹子素化学性质
- 熔点 :132 °C
- 沸点 :710.8±60.0 °C(Predicted)
- 密度 :1.114±0.06 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
- 酸度系数(pKa) :4.50±1.00(Predicted)
- 形态 :Yellow solid.
- 颜色 :Yellow
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Garcinol is prone to oxidation. Protect from exposure to air.
- LogP :11.546 (est)
山竹子素性质、用途与生产工艺
- 生物活性 Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶的特性，IC50 分别为 0.66 µM 和 7.39 µM。Garcinol 还抑制组蛋白乙酰转移酶 (HATs, IC50=7 μM) 和 p300/CPB 相关因子 (PCAF, IC50=5 μM)。Garcinol 具有抗炎和抗癌活性。
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靶点
Human Endogenous Metabolite
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体外研究
Garcinol (10-50 µM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.
Garcinol (10-50 µM; 24-72 hours) induces apoptosis in HNSCC cells.
Garcinol (50 µM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.
Cell Proliferation Assay
Cell Line: CAL27 and UMSCC1 cells Concentration: 10, 25, 50 µM Incubation Time: 24, 48, and 72 hours Result: Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner. Apoptosis Analysis
Cell Line: CAL27 and UMSCC1 cells Concentration: 10, 25, 50 µM Incubation Time: 24, 48, and 72 hours Result: Induced apoptosis in HNSCC cells. Western Blot Analysis
Cell Line: CAL27 cells Concentration: 50 µM Incubation Time: 1, 2, 4, 6 hours Result: Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner. -
体内研究
Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth.
Animal Model: Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors Dosage: 1 and 2 mg/kg Administration: I.p.; five times/week for 4 consecutive weeks Result: Induced significant inhibition of tumor growth.
山竹子素上下游产品信息
上游原料
下游产品
山竹子素 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-107569
- 产品名称：山竹子素 Garcinol
- CAS编号：78824-30-3
- 包装：1mg
- 价格：800元
- 更新日期：2024/11/08
- 产品编号：HY-107569
- 产品名称：山竹子素 Garcinol
- CAS编号：78824-30-3
- 包装：5mg
- 价格：2450元
山竹子素生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
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