山竹子素

生物活性靶点体外研究体内研究山竹子素试剂级价格

山竹子素

CAS号:78824-30-3
英文名:garcinol
中文名:山竹子素
CBNumber:CB11347121
分子式:C38H50O6
分子量:602.8
MOL File:78824-30-3.mol

山竹子素化学性质

熔点 :132 °C
沸点 :710.8±60.0 °C(Predicted)
密度 :1.114±0.06 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
酸度系数(pKa) :4.50±1.00(Predicted)
形态 :Yellow solid.
颜色 :Yellow
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Garcinol is prone to oxidation. Protect from exposure to air.
LogP :11.546 (est)

山竹子素性质、用途与生产工艺

生物活性 Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶的特性，IC50 分别为 0.66 µM 和 7.39 µM。Garcinol 还抑制组蛋白乙酰转移酶 (HATs, IC50=7 μM) 和 p300/CPB 相关因子 (PCAF, IC50=5 μM)。Garcinol 具有抗炎和抗癌活性。
靶点

Human Endogenous Metabolite

体外研究

Garcinol (10-50 µM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.
Garcinol (10-50 µM; 24-72 hours) induces apoptosis in HNSCC cells.
Garcinol (50 µM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.

Cell Proliferation Assay

Cell Line:	CAL27 and UMSCC1 cells
Concentration:	10, 25, 50 µM
Incubation Time:	24, 48, and 72 hours
Result:	Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner.

Apoptosis Analysis

Cell Line:	CAL27 and UMSCC1 cells
Concentration:	10, 25, 50 µM
Incubation Time:	24, 48, and 72 hours
Result:	Induced apoptosis in HNSCC cells.

Western Blot Analysis

Cell Line:	CAL27 cells
Concentration:	50 µM
Incubation Time:	1, 2, 4, 6 hours
Result:	Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.

体内研究

Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth.

Animal Model:	Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors
Dosage:	1 and 2 mg/kg
Administration:	I.p.; five times/week for 4 consecutive weeks
Result:	Induced significant inhibition of tumor growth.