款冬酮

生物活性体外研究体内研究款冬酮试剂级价格

款冬酮

CAS号:104012-37-5
英文名:Tussilagone
中文名:款冬酮
CBNumber:CB11253147
分子式:C23H34O5
分子量:390.51
MOL File:104012-37-5.mol

款冬酮化学性质

沸点 :471.3±35.0 °C(Predicted)
密度 :1.07±0.1 g/cm3 (20 ºC 760 Torr)
形态 :Solid
颜色 :White to off-white

安全信息

安全说明 :24/25
海关编码 :29389090

款冬酮性质、用途与生产工艺

生物活性 Tussilagone，Tussilago farfara的主要活性成分，具有抗炎作用。Tussilagone 改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。Tussilagone 抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应，提高其生存率。
体外研究

Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages.
体内研究

Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration.
化学性质白色结晶性粉末，溶于乙醚、氯仿、乙酸乙酯、甲醇，不溶于水，来源于菊科款冬Tussilago farfara的花蕾，千里光 Senecio kleinia Less 根。
用途款冬酮具有升压，呼吸兴奋作用，提高心肌收缩力，抗血小板聚集作用，钙通道阻断活性，镇咳，祛痰，平喘的作用。
用途用于含量测定/鉴定/药理实验等
药理药效:有升压、呼吸兴奋作用