阿魏酸甲酯

生物活性靶点体外研究阿魏酸甲酯试剂级价格

阿魏酸甲酯

CAS号:2309-07-1
英文名:FERULIC ACID METHYL ESTER
中文名:阿魏酸甲酯
CBNumber:CB0448918
分子式:C11H12O4
分子量:208.21
MOL File:2309-07-1.mol

阿魏酸甲酯化学性质

熔点 :62-65°C
沸点 :163 °C(Press: 1 Torr)
密度 :1.204±0.06 g/cm3(Predicted)
储存条件 :2-8°C
溶解度 :Acetone (Slightly), Chloroform (Slightly), Ethyl Acetate (Sparingly)
形态 :Solid
酸度系数(pKa) :8.88±0.18(Predicted)
颜色 :White to Off-White
水溶解性 :Slightly soluble in water.
LogP :2.209 (est)
CAS 数据库 :2309-07-1(CAS DataBase Reference)
NIST化学物质信息 :2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester(2309-07-1)

安全信息

危险类别码 :36/37/38
安全说明 :26-36/37/39
RTECS号 :GD9470000
海关编码 :2918999090

阿魏酸甲酯性质、用途与生产工艺

生物活性 Ferulic acid methyl ester (Methyl ferulate) 是从 Stemona tuberosa 中分到的阿魏酸衍生物，具有抗氧化、抗炎作用。Ferulic acid methyl ester 能够透过细胞膜和血脑屏障，清除自由基，可用于神经退行性疾病的研究。在原发性骨髓源性巨噬细胞中，Ferulic acid methyl ester 抑制 COX-2 的表达，降低 p-p38 和 p-JNK 的水平。
靶点

p38

体外研究

Ferulic acid methyl ester (25 µg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.
Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs).
Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK.

Cell Viability Assay

Cell Line:	Primary bone marrow derived-macrophages (BMDMs)
Concentration:	25 µg/mL
Incubation Time:	6 h, 18 h, 48 h
Result:	Showed no cytotoxic effects on BMDMs.

Western Blot Analysis

Cell Line:	RAW 246.7 cells
Concentration:	10 µg/mL and 25 µg/mL
Incubation Time:	For 1 h before stimulation with LPS
Result:	Significantly suppressed COX-2 expression at 25 µg/mL.