2-4-羧苯基四甲基咪唑烷-1-氧-3-氧化物
- CAS号:148819-94-7
- 英文名:CARBOXY-PTIO
- 中文名:2-4-羧苯基四甲基咪唑烷-1-氧-3-氧化物
- CBNumber:CB0359762
- 分子式:C14H16KN2O4*
- 分子量:315.39
- MOL File:148819-94-7.mol
- 熔点 :141-143°C
- 储存条件 :2-8°C
- 溶解度 :H2O: >20 mg/mL
- 形态 :solid
- 颜色 :blue
- 水溶解性 :Soluble in water. Also soluble in ethanol, methanol, DMSO or DMF.
- 稳定性 :Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
- CAS 数据库 :148819-94-7(CAS DataBase Reference)
- 安全说明 :24/25
- WGK Germany :3
- 海关编码 :2918999090
2-4-羧苯基四甲基咪唑烷-1-氧-3-氧化物性质、用途与生产工艺
- 生物活性 Carboxy-PTIO potassium 是一种有效的一氧化氮 (NO) 清除剂，能与 NO 快速反应产生 NO2。Carboxy-PTIO potassium 通过对脂多糖诱导大鼠模型中 NO 的直接清除作用，可预防低血压和内毒素休克。
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体外研究
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone.Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei.Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells .
Western Blot Analysis
Cell Line: A375-S2 cells Concentration: 200 μM Incubation Time: 1 h prior to physalin A; 24 hours Result: Diminished physalin A-induced procaspase-3 and PARP cleavage. -
体内研究
Carboxy-PTIO (intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats.
Animal Model: SD rats Dosage: 0.056-1.70 mg/kg/min Administration: Intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min Result: Exhibited a potent therapeutic value in endotoxin shock through the direct scavenging action against NO.
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