地司特泰

生物活性体外研究体内研究地司特泰试剂级价格

地司特泰

CAS号:272105-42-7
英文名:Disitertide
中文名:地司特泰
CBNumber:CB01518504
分子式:C68H109N17O22S2
分子量:1580.84
MOL File:272105-42-7.mol

地司特泰化学性质

沸点 :1968.7±65.0 °C(Predicted)
密度 :1.327
储存条件 :Store at -20°C
溶解度 :DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
酸度系数(pKa) :3.15±0.10(Predicted)
形态 :Solid
颜色 :White to off-white
InChIKey :IUYPEUHIWDMJLM-INGCBPSVNA-N

地司特泰性质、用途与生产工艺

生物活性 Disitertide (P144) TFA 是转化生长因子 TGFβ1 的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide (P144) 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。

体外研究

Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines.

Western Blot Analysis

Cell Line:	Mouse embryo osteoblast precursor MC3T3-E1 cells.
Concentration:	100 μg/mL.
Incubation Time:	4 h.
Result:	Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.

体内研究

Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.

Animal Model:	Human hypertrophic scars were implanted in 60 nude mice.
Dosage:	300 μg/mL was added the Lipogel.
Administration:	Topical application daily administered.
Result:	Successful shedding was achieved in 83,3% of the xenografts.