没食子酸一水合物

性质作用生物活性靶点体外研究体内研究没食子酸一水合物试剂级价格

没食子酸一水合物

CAS号:5995-86-8
英文名:Gallic acid monohydrate
中文名:没食子酸一水合物
CBNumber:CB00134921
分子式:C7H8O6
分子量:188.13
MOL File:5995-86-8.mol

没食子酸一水合物化学性质

熔点 :252 °C (dec.)(lit.)
密度 :1.694
闪点 :250 °C
储存条件 :Keep in dark place,Sealed in dry,Room Temperature
溶解度 :It is soluble in alcohol, ether, glycerol, acetone negligible in benzene, chloroform, petroleum ether.
形态 :Solid
颜色 :White to cream
水溶解性 :15 g/l (20 ºC)
敏感性 :Hygroscopic
Merck :14,4345
BRN :2050274
稳定性 :Light Sensitive
InChI :InChI=1S/C7H6O5.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;/h1-2,8-10H,(H,11,12);1H2
InChIKey :IUTKPPDDLYYMBE-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC(O)=C(O)C(O)=C1.[H]O[H]
CAS 数据库 :5995-86-8(CAS DataBase Reference)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26-36-24/25
WGK Germany :2
RTECS号 :LW7525000
F :8-9-23
TSCA :Yes
海关编码 :29182900

一水没食子酸化学药品说明书

六味地黄丸—没食子酸的测定—毛细管区带电泳法|药物分析方法信息
六味地黄丸—没食子酸/泽泻醇A乙酸酯/番木鳖苷/莫罗苷/羟基芍药苷/梓醇/苯甲酰羟基芍药苷/泽泻醇B/熊果酸—高效液相色谱/电喷雾电离—质谱分析|药物分析方法信息

没食子酸一水合物性质、用途与生产工艺

性质一水没食子酸在常温常压下为白色至米白色固体状，其具有较强的酸性。
作用
一水没食子酸是一种天然多羟基酚类化合物，具有抑制环氧合酶-2 (COX-2) 的自由基清除作用；在制药、食品、轻工诸方面均有广泛用途，也用作分析试剂，还用于制造墨水及照相业。
生物活性 Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate 是一种天然多羟基酚类化合物，具有抑制环氧合酶-2 (COX-2) 的自由基清除作用。Gallic acid hydrate 具有多种活性，如抗菌、抗氧化、抗菌、抗炎和抗肿瘤活性。
靶点

COX-2

Human Endogenous Metabolite
体外研究

Gallic acid is an antioxidant which can inhibit both COX-2. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis.
体内研究

The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups.
化学性质白色或淡黄色针状晶体，或棱柱状晶体。有绢丝光泽，味微酸。溶于乙醇、丙酮、乙二醇，微溶于水、乙醚。
用途用于制造噻嗪染料、恶嗪染料、药物等
用途用作电化分析中的去极剂；用于还原磷钼酸；用于检定锑、钡、铋、钙、铈和铜等；用于测定磷、亚硝酸盐、银、钍和钛等
用途试验游离矿酸、二羟基丙酮和生物碱等，电化分析中的去极剂，还原磷钼酸，检定锑、钡、铋、钙、铈和铜等。测定磷、亚硝酸盐、银、钍和钛等。
类别有毒物质
毒性分级中毒
急性毒性静脉-小鼠 LD50: 320 毫克/公斤
可燃性危险特性可燃, 火场排出辛辣刺激烟雾
储运特性库房低温, 通风, 干燥
灭火剂水, 二氧化碳, 干粉, 砂土