17α-雌二醇
- CAS号:57-91-0
- 英文名:Estradiol
- 中文名:17α-雌二醇
- CBNumber:CB00129057
- 分子式:C18H24O2
- 分子量:272.39
- MOL File:57-91-0.mol
- 熔点 :176-180 °C(lit.)
- 沸点 :355.44°C (rough estimate)
- 比旋光度 :D20 +53 to +56° (c = 0.9 in dioxane)
- 密度 :1.0708 (rough estimate)
- 折射率 :1.4800 (estimate)
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :ethanol: 50 mg/mL, clear, colorless
- 形态 :powder
- 酸度系数(pKa) :10.27±0.60(Predicted)
- 颜色 :white with slight yellow
- 水溶解性 :3.9mg/L(25 ºC)
- Merck :14,3704
- CAS 数据库 :57-91-0(CAS DataBase Reference)
- NIST化学物质信息 :Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
- EPA化学物质信息 :Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)
- 危险品标志 :T,Xn
- 危险类别码 :45-48-40
- 安全说明 :53-45-24/25-22
- 危险品运输编号 :UN 2811 6.1/PG 2
- WGK Germany :3
- RTECS号 :KG3750000
- F :8-10
- 海关编码 :29372390
α-雌二醇 化学药品说明书
雌二醇|药典2005版
雌二醇缓释贴片—雌二醇的测定—高效液相色谱法|药物分析方法信息
17α-雌二醇性质、用途与生产工艺
- 生物活性 Alpha-Estradiol 是一种雌性激素，是 5α-reductase 抑制剂，有潜力用于雄原性脱发的研究。
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靶点
Human Endogenous Metabolite
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体外研究
Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
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体内研究
Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.
- 用途 治疗功能性子宫出血、原发性闭经、绝经期综合症等。
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用途
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17α-stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain.17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer disease and ischemic stroke.
- 更新日期：2024/11/11
- 产品编号：XW00579101
- 产品名称：Α-雌二醇
- CAS编号：57-91-0
- 包装：200MG
- 价格：229元
- 更新日期：2024/11/08
- 产品编号：HY-B0141A
- 产品名称：α-雌二醇 Alpha-Estradiol
- CAS编号：57-91-0
- 包装：100mg
- 价格：750元
- 公司名称：GEDEON RICHTER PLC
- 联系电话：--
- 电子邮件：medinfo@richter.hu
- 国家：匈牙利
- 产品数：15
- 优势度：58
