99755-59-6
基本信息
罗替戈汀碱
罗替戈汀杂质
罗替哥汀杂质
罗替戈汀 100MG
ROTIGOTINE(S构型)
(S)-5,6,7,8-四氢-6-(丙基(2-(2-噻吩基)乙基)氨基)-1-萘酚
Neupro
N 0923
SPM 962
Rotigotine
S(-)-N-0437
Rotigotine (Base)
ROTIGOTINE USP/EP/BP
(S)-2-[Propyl[2-(2-thienyl)ethyl]amino]tetralin-5-ol
[S,(-)]-2-[Propyl[2-(2-thienyl)ethyl]amino]tetralin-5-ol
物理化学性质
| 熔点 | 78 °C |
| 沸点 | 470.1±45.0 °C(Predicted) |
| 密度 | 1.15±0.1 g/cm3(Predicted) |
| 储存条件 | room temp |
| 溶解度 | DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml |
| 水溶解性 | 不溶于水 |
| 酸度系数(pKa) | 10.49±0.40(Predicted) |
| 形态 | 粉末晶体 |
| 颜色 | 白色到近乎白色 |
| 主要应用 | pharmaceutical pharmaceutical small molecule |
| InChI | InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1 |
| InChIKey | KFQYTPMOWPVWEJ-INIZCTEOSA-N |
| SMILES | C1(O)=C2C(C[C@@H](N(CCC)CCC3SC=CC=3)CC2)=CC=C1 |
安全数据
| 危险性符号(GHS) |   GHS07,GHS08 |
| 警示词 | 警告 |
| 危险性描述 | H336-H362-H361 |
| 防范说明 | P261-P271-P304+P340-P312-P403+P233-P405-P501-P201-P202-P281-P308+P313-P405-P501-P201-P260-P263-P264-P270-P308+P313 |
| 危险品标志 | Xn |
| 危险类别码 | 22 |
| WGK Germany | WGK 3 |
| 海关编码 | 2934990002 |
| 存储类别 | 11 - Combustible Solids |
| 毒害物质数据 | 99755-59-6(Hazardous Substances Data) |
常见问题列表
罗替戈汀为非麦角类多巴胺受体刺激药，具有刺激脑部多巴胺受体的作用，用作柏金逊症的单一治疗或与左旋多巴共用。
罗替戈汀可能会引起敏感反应。其他的副作用如头晕，头痛，突发性昏睡，失眠，肠胃不适，便秘，体位性低血压等。
| Target | Value |
| Dopamine receptor |
Rotigotine (N-0437; N-0923) has a 10-fold selectivity for D3 (pK
i
9.2) receptors compared with D2, D4 and D5 (pK
i
8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pK
i
7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC
50
respectively: 9.0, 9.4-8.6, 9.7).
Rotigotine (10 µM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 µM) slightly protects dopaminergic neurons against MPP
+
toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.
In primed rats, Rotigotine (N-0437; N-0923; 0.035, 0.1 and 0.35 mg/kg) induces contralateral turning behavior in a dose dependent manner. In drug naive rats, the turning behavior induced by Rotigotine, either alone or in combination with SCH 39166, is reduced compared to primed rats.
罗替戈汀价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/07/06 | 46654 | 罗替高汀 Rotigotine | 99755-59-6 | 100mg | 2443元 |
| 2026/07/06 | S4274 | 罗替戈汀 Rotigotine | 99755-59-6 | 10mg | 801.08元 |
| 2026/07/06 | S4274 | 罗替戈汀 Rotigotine | 99755-59-6 | 50mg | 3080.65元 |