37318-06-2
基本信息
elaiophylin
GopalaMicin
EfoMycine E
Azalomycin B
255-E, 5001B, 56-62, 846 I, SNA 4606-3, AzaloMycin B, GopalaMicin, SalboMycin
物理化学性质
| 熔点 | 179-182℃ |
| 沸点 | 1080.5±65.0 °C(Predicted) |
| 密度 | 1.25 |
| 储存条件 | -20°C冷冻 |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 酸度系数(pKa) | 12.18±0.70(Predicted) |
| 形态 | 白色至类白色固体 |
| 颜色 | 白色至灰白色 |
常见问题列表
Autophagy
Elaiophylin-mediated autophagy inhibition and lysosomal dysfunction affect ovarian cancer cell survival during hypoxia. Exposure to Elaiophylin (0.025-0.5 μM; 24 hours) causes a significant increase in ovarian cancer SKOV3 cell death in hypoxia conditions.
In both the SKOV3 and A2780 cell lines, Elaiophylin (0.25, 0.5, 0.75 μM; 24 hours) treatment leads to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner.
Cell Viability Assay
| Cell Line: | Ovarian cancer SKOV3 cells. |
| Concentration: | 0.025, 0.05, 0.1, 0.2, 0.5 μM |
| Incubation Time: | 24 hours |
| Result: | Caused a significant increase in ovarian cancer SKOV3 cells death in hypoxia conditions. |
Western Blot Analysis
| Cell Line: | Ovarian cancer SKOV3 cells; A2780 cells |
| Concentration: | 0.25, 0.5, 0.75 μM |
| Incubation Time: | 24 hours |
| Result: | Treatment led to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner. |
Treatment with 2 mg/kg Elaiophylin (given i.p. every 2 days for 21 days; in BALB/C athymic mice) significantly suppresses ovarian cancer SKOV3 cells growth compared with DMSO treatment, resulting in a 72% decrease in the average daily tumor growth rate compared with DMSO treatment .
Lower doses of Elaiophylin as a single agent exert significant antitumor activity, while higher doses lead to intestinal toxicity. Administration of a lower dose (2 mg/kg) of Elaiophylin as a single agent achieves a significant antitumor effect without toxicity in an orthotopic ovarian cancer model with metastasis. Toxic reactions are observed only in the 8 mg/kg group.
| Animal Model: | 4-wk-old BALB/C athymic mice with ovarian cancer SKOV3 cells |
| Dosage: | 1 or 2 mg/kg |
| Administration: | Given i.p. every 2 days for 21 days |
| Result: | Treatment with 2 mg/kg significantly suppressed ovarian cancer SKOV3 cells growth compared with DMSO treatment. |
洋橄榄叶素价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-15184 | 洋橄榄叶素 Elaiophylin | 37318-06-2 | 1mg | 3920元 |
| 2024/08/19 | HY-15184 | 洋橄榄叶素 Elaiophylin | 37318-06-2 | 5mg | 9760元 |
| 2024/01/25 | HY-15184 | 洋橄榄叶素 Elaiophylin | 37318-06-2 | 10 mg | 5200元 |