309271-94-1
基本信息
CS-1439
Inauhzin
Inauhzin(INZ)
Inauhzin, >=98%
10-[1-Oxo-2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)butyl]-10H-phenothiazine
2-(9H-[1,2,4]TRIAZINO[6,5-B]INDOL-3-YLTHIO)-1-(10H-PHENOTHIAZIN-10-YL)BUTAN-1-ONE
1-Butanone, 1-(10H-phenothiazin-10-yl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)-
2-((5H-[1,2,4]Triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one
1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin)
物理化学性质
| 沸点 | 773.6±70.0 °C(Predicted) |
| 密度 | 1.50±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | ≥23.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| 酸度系数(pKa) | 10.24±0.50(Predicted) |
| 形态 | 固体 |
| 颜色 | Light yellow to yellow |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H317 |
| 防范说明 | P280-P305+P351+P338 |
INAUHZIN价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-15869 | Inauhzin | 309271-94-1 | 1 mg | 350元 |
| 2025/02/08 | HY-15869 | INAUHZIN Inauhzin | 309271-94-1 | 5mg | 650元 |
| 2025/02/08 | HY-15869 | INAUHZIN Inauhzin | 309271-94-1 | 10mM * 1mLin DMSO | 671元 |
常见问题列表
| Target | Value |
|
SIRT1
() | |
|
p53
() |
Inauhzin (10 µM) induces p53 levels as effectively as actinomycin D (10 nM), and mediates p53-dependent cytotoxicity through its specific functional groups in human lung carcinoma H460 cells. Inauhzin (2 µM) induces p53 level and activity as well as p53-dependent apoptosis. Inauhzin also stabilizes p53 and inhibits its ubiquitylation. Inauhzin induces acetylation of p53 in H460 cells, but not tubulin, which is affected by knockdown of SIRT1. Inauhzin (0-2 µM) significantly enhances the expression level and activity of p53 in HCT116 p53+/+ cells and enhances the expression level and activity of p53 in H460 cells in a dose-dependent manner. Inauhzin and Nutlin-3 demonstrate synergistic cytotoxicity in the Nutlin-3 low-sensitive cells. Inauhzin and Nutlin-3 synergistically induce p53-dependent apoptosis. Inauhzin targets both SirT1 and IMP dehydrogenase 2 (IMPDH2), and acts as a potent p53 activator.
Inauhzin (30 mg/kg, i.p.) effectively induces apoptosis and suppresses tumour growth of H460 xenograft harbouring p53. Inauhzin (30 mg/kg, i.p.) reduces the HCT116 tumor volume by appr 70%. Inauhzin (15 mg/kg) in combination with 150 mg/kg of Nutlin-3 demonstrates a significant synergy on p53 induction, apoptosis and tumor suppression of HCT116 p53+/+ xenografts.