2309172-48-1
物理化学性质
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO:20.07(Max Conc. mg/mL);50.01(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);24.92(Max Conc. mM) |
| 形态 | 结晶固体 |
| 颜色 | Light yellow to yellow |
LDN-192960 HYDROCHLORIDE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-13455A | LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride | 2309172-48-1 | 5mg | 2900元 |
| 2024/08/19 | HY-13455A | LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride | 2309172-48-1 | 10mM * 1mLin DMSO | 3190元 |
| 2024/08/19 | HY-13455A | LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride | 2309172-48-1 | 10mg | 4700元 |
常见问题列表
IC50: 10 nM (Haspin); 48 nM (DYRK2)
LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC 50 <1 μM), including CLK1 (IC 50 =0.21 μM), DYRK1A (IC 50 = 0.10 μM), DYRK2 (IC 50 =2 nM), DYRK3 (IC 50 =19 nM) and PIM1 (IC 50 =0.72 μM).LDN-0192960 hydrochloride (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC 50 of 1.17 μM.LDN-0192960 hydrochloride (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC 50 of 0.02 μM.