181586-07-2

Ono 3403 is a synthetic serine protease inhibitor hat inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Oral administration of the potent serine protease inhibitor ONO-3403 has an antitumor effect on malignant tumors suggested by the growth inhibition of mouse skin tumors in research.

ONO-3403 是一种具有口服活性的丝氨酸蛋白酶 (serine protease) 抑制剂。ONO-3403 抑制LPS 诱导的TNF-α 和一氧化氮的产生。ONO-3403 抑制细胞生长，诱导细胞凋亡 (apoptosis)，对恶性肿瘤具有抗肿瘤作用。