供应商 相关产品 基本信息 理化性质 物理化学性质 安全数据 16561-29-8(安全特性,毒性,储运) 常见问题列表 知名试剂公司产品信息 佛波醇12-十四酸酯13-乙酸酯价格(试剂级)
网站主页 > Cas数据库列表 > 16561-29-8

16561-29-8

供应商 相关产品 基本信息 理化性质 物理化学性质 安全数据 16561-29-8(安全特性,毒性,储运) 常见问题列表 知名试剂公司产品信息 佛波醇12-十四酸酯13-乙酸酯价格(试剂级)

产品图片

基本信息

英文
PHORBOL 12-MYRISTATE 13-ACETATE
中文
佛波醇12-十四酸酯13-乙酸酯
英文名称
12-O-TETRADECANOYLPHORBOL 13-ACETATE
12-TETRADECANOYL PHORBOL 13-ACETATE
(1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL (12-MYRISTOYL-13-ACETYL)
PMA
TPA
,9aalpha))-
1,6,8-beta-tetramethyl-l)-9a-acetate9-myristate
12-o-tetradecanoylphorbolacetate
12-o-tetradekanoylphorbol-13-acetat
12-tetradecanoylphorbol13-monoacetate
13-o-acetylphorbol12-myristate
4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy
abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram
CAS
16561-29-8
中文名称
佛波醇12-十四酸酯13-乙酸酯
豆蔻酰佛波醇乙酯
乙酸佛波酯 PMA
乙酸佛波酯
分子式
C36H56O8
MDL 编号
MFCD00036736
分子量
616.83
MOL 文件
16561-29-8.mol

理化性质

沸点 
571.87°C (rough estimate)
密度 
1.17±0.1 g/cm3 (20 ºC 760 Torr)
折射率 
1.4900 (estimate)
酸度系数(pKa)
11.19±0.70(Predicted)
形态
Fine Crystalline Powder
颜色
Off-white to light yellow
水溶解性 
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
敏感性 
Light Sensitive
BRN 
2407201
InChIKey
PHEDXBVPIONUQT-RGYGYFBISA-N
CAS 数据库
16561-29-8(CAS DataBase Reference)
EPA化学物质信息
12-O-Tetradecanoylphorbol 13-acetate (16561-29-8)

物理化学性质

储存条件 
−20°C

溶解度 
DMSO: DMSO solutions can be stored dark at −20?#x00b0;C for at least six months.soluble

安全数据

危险品标志 
Xi
危险类别码 
R38
安全说明 
S36/37
危险品运输编号 
2928
WGK Germany 
3

RTECS 
QH4377000

RTECS号
QH4377000


8-10
HazardClass 
6.1(a)
危险等级
6.1(a)
PackingGroup 
II
包装类别
II
海关编码
29153900
海关编码 
29153900
毒害物质数据
16561-29-8(Hazardous Substances Data)

16561-29-8(安全特性,毒性,储运)

储运特性
库房通风低温干燥; 与食品分开储运
毒性分级
剧毒
急性毒性
静脉- 小鼠 LD50: 0.309 毫克/公斤
可燃性危险特性
可燃, 火场排出辛辣刺激烟雾
类别
有毒物品
灭火剂
水, 砂土, 泡沫

常见问题列表

佛波酯
佛波酯又称佛波醇酯、大戟二萜醇酯,是巴豆油中的成分,十四烷酸和佛波醇形成的酯。已证实是一种促癌剂。其促癌活性大小不一,活性最高的是12-邻十四烷酰大戟二萜醇-13-乙酸酯(TPA),其余依次为大戟二萜醇-12,13-双癸酸酯、大戟二萜醇-12,13-双丁酸酯、4-邻甲基大戟二萜酸-12-十四烷酰-13-乙酸酯、大戟二萜醇-12,13-双癸酸酯。促癌机制不很清楚,近期认为与启动细胞膜相互作用,促进第二信使的合成和增加蛋白激酶活性有关。 佛波酯能激活导致细胞增殖或分化的信号通路而具有促进细胞癌变的作用。其中活性最高的是12-邻-14-烷酰佛波醇-13-乙酸酯。
生物活性
Phorbol 12-myristate 13-acetate (PMA, 12-O-Tetradecanoylphorbol-13-acetate, TPA)是一种有效的PKC激活剂,在纳摩尔浓度范围内具有活性作用。Phorbol 12-myristate 13-acetate (PMA)可诱导sphingosine-1-phosphate (S1P)。
靶点

PKC

11.7 nM (EC 50 )


体外研究

In order to examine the role of PKC in p38MAPK phosphorylation, the cells are stimulated with the PKC activator, PMA (100 nM), which mimics the binding of DAG, the natural activator of PKC, to the C1 region of the PKCs. p38MAPK phosphorylation by PMA is observed in the two cell types similar to that observed by GnRH in αT3-1 cells, that is, a slow sustained activation (3.2-fold and 3.6-fold, respectively at 30 min). The paradoxical findings that PKCs activated by GnRH and PMA play a differential role in p38MAPK phosphorylation may be explained by differential localization of the PKCs. Basal, GnRH- and PMA- stimulation of p38MAPK phosphorylation in αT3-1 cells is mediated by Ca 2+ influx via voltage-gated Ca 2+ channels and Ca 2+ mobilization, while in the differentiated LβT2 gonadotrope cells it is mediated only by Ca 2+ mobilization.
THP-1 cells are differentiated into macrophage-like cells (THP-1 macrophages) by incubation in the presence of PMA (200 ng/mL; 1-5 days), which leads to a macrophage-like phenotype characterized by changes in morphology and increased cell surface expression of CD11 and CD14.
In the monocytic cell line THP-1, PMA results in a more differentiated phenotype than VD3, according to adherence, loss of proliferation, phagocytosis of latex beads, and expression of CD11b and CD14.


体内研究

PMA is a PKC agonist, which reverses the damage induced by 5-hydroxydecanoic acid (5-HD). Thus, activation of the mitoKATP protected mitochondrial function in SOD and MDA via the PKC pathway.


知名试剂公司产品信息

佛波醇12-十四酸酯13-乙酸酯价格(试剂级)

佛波醇12-十四酸酯13-乙酸酯价格(试剂级)
更新日期产品编号产品名称包装价格
2022/04/29C35615佛波醇12-十四酸酯13-乙酸酯
Phorbol 12-myristate 13-acetate, 97%
1mg1772元
2022/04/29C35615佛波醇12-十四酸酯13-乙酸酯
Phorbol 12-myristate 13-acetate, 97%
5mg6525元
2022/04/29HY-18739佛波醇12-十四酸酯13-乙酸酯
Phorbol 12-myristate 13-acetate
1 mg550元

供应商信息更多