90365-57-4
基本信息
IndolactaM
Brn 4711877
()-Indolactam V
(-)-INDOLACTAM V
(-)-Indolactam V
(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl)
3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym
(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)-
物理化学性质
| 沸点 | 584.0±50.0 °C(Predicted) |
| 密度 | 1.166±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMSO：>10mg/mL，澄清 |
| 酸度系数(pKa) | 14.39±0.10(Predicted) |
| 形态 | 白色粉末 |
| 稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达2个月。 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313 |
| WGK Germany | 3 |
| RTECS号 | UY8547000 |
吲哚内酰胺 V价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-12307 | 吲哚内酰胺 V (-)-Indolactam V | 90365-57-4 | 1mg | 1800元 |
| 2024/01/25 | HY-12307 | 吲哚内酰胺 V (-)-Indolactam V | 90365-57-4 | 10mM * 1mLin DMSO | 4376元 |
| 2024/01/25 | HY-12307 | 吲哚内酰胺 V (-)-Indolactam V | 90365-57-4 | 5mg | 6600元 |
常见问题列表
|
PKCη-CRD2 3.36 nM (Ki) |
PKCη-C1B 5.5 nM (Kd) |
PKCε-C1B 7.7 nM (Kd) |
PKCδ-C1B 8.3 nM (Kd) |
PKCθ-C1B 8.7 nM (Kd) |
PKCβ-C1A-long 18.9 nM (Kd) |
PKCα-C1A-long 20.8 nM (Kd) |
PKCβ-C1B 137 nM (Kd) |
PKCγ-C1A 138 nM (Kd) |
PKCγ-C1B 213 nM (Kd) |
PKCγ-CRD2 1030 nM (Ki) |
PKCδ-C1A 1900 nM (Kd) |
PKCη-C1A 3770 nM (Kd) |
PKCα-C1B-long 4000 nM (Kd) |
PKCε-C1A 4110 nM (Kd) |
(-)-Indolactam V is a PKC activator, with K i s of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and has antitumor activity. (-)-Indolactam V shows K d s of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), respectively. (-)-Indolactam V (20 nM-5 μM) dose-dependently affects multiple hESC lines, such as HUES 2, 4 and 8. (-)-Indolactam V also increases the mRNA levels of Pdx1, HNF6, PTF1A, SOX9, HB9 and PROX1. In addition, (-)-Indolactam V (300 nM) functions in both mouse and human cells and confirms that some signals for pancreatic development.