16290-26-9
基本信息
3,4-二羟基苄胺氢溴酸盐
3,4-二羟基苄胺
3,4-二羟基苯甲胺氢溴酸盐
4-(AMINOMETHYL)CATECHOL HYDROBROMIDE
DHBA
DHBA HYDROBROMIDE
4-(aminomethyl)pyrocatechol hydrobromide
3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE, 9 8%
4-(Aminomethyl)catechol hydrobromide, DHBA hydrobromide
3,4-Dihydroxybenzylamine·hydrogen bromide
4-(Aminomethyl)pyrocatechol·hydrobrominate
物理化学性质
| 熔点 | 184-186 °C(lit.) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 形态 | 结晶粉末 |
| 颜色 | 浅米色 |
| 敏感性 | 吸湿性 |
| BRN | 4002646 |
| CAS 数据库 | 16290-26-9(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| 危险品标志 | Xi |
| 危险类别码 | R36/37/38 |
| 安全说明 | S26-S36 |
| WGK Germany | 3 |
| F | 10 |
| 海关编码 | 29222900 |
图谱信息
3,4-二羟基苄胺·氢溴酸(16290-26-9)质谱(MS)3,4-二羟基苄胺·氢溴酸(16290-26-9)核磁图(1HNMR)3,4-二羟基苄胺·氢溴酸(16290-26-9)红外图谱(IR1)3,4-二羟基苄胺·氢溴酸(16290-26-9)红外图谱(IR2)3,4-二羟基苄胺·氢溴酸(16290-26-9)Raman光谱知名试剂公司产品信息
3,4-二羟基苄胺·氢溴酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | 22857 | 3,4-二羟基苯甲胺 氢溴酸盐 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 250mg | 625元 |
| 2024/11/08 | 22857 | 3,4-二羟基苯甲胺 氢溴酸盐 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 1g | 1568元 |
| 2024/11/08 | 22857 | 3,4-二羟基苯甲胺 氢溴酸盐 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 5g | 7419元 |
常见问题列表
3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of all melanoma cell lines with an IC 50 of 100 μM, while the SK-MELB cell line exhibits an IC 50 of 122 μM. The IC 50 values are 30, 84,90, and 68 μM for Human SK-MEL-30, SK-MEL-2, SK-MEL-3,RPMI-7951 cells, respectively. It exhibits IC 50 values of 10, 25, 67, and 184 μM for S91A,S91B, L1210, and SCC-25 cells, respectively.3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) cytotoxicity in SK-MEL-2 and SK-MEL-28 cell lines can be enhanced by application of buthionine sulfoximine (BSO). BSO treatment sensitizes marginally pigmented cells to the effects of 3,4-DHBA, and the presence of decreses IC 50 values of 3,4-DHBA by 127% in the SK-MEL-28 cell line and by 148% in the SK-MEL-2 cell line.
Cell Viability Assay
| Cell Line: | Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines |
| Concentration: | 1 μM-10 mM |
| Incubation Time: | 48 hours |
| Result: | Inhibited melanoma cell Lines growth. |
3,4-Dihydroxybenzylamine hydrobromide (intraperitoneal injection; 1000 mg/kg; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose. 3,4-Dihydroxybenzylamine hydrobromide (intraperitoneal injection; 200-800 mg/kg; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days for 0 mg/kg, 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively.
| Animal Model: | C57BL/6 mice with B6D2F1 cells |
| Dosage: | 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Exhibited increased life-span of 44%,46%, 70% and 50% for 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively. |