1210-83-9
基本信息
3-(N-ACETYL-2-AMINOETHYL)-5-HYDROXYINDOLE
ACETYL-5-HYDROXY TRYPTAMINE
ACETYL-SEROTONINE
ACETYL-SEROTONIN, N-
AKOS BC-0717
N-[2-(5-HYDROXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE
N-ACETYL-5-HYDROXYTRYPTAMINE
N-ACETYLSEROTONIN
N-ALPHA-ACETYL SEROTONINE
NORMELATONIN
SEROTONIN, N-ACETYL-
N-Acetyl-5-hydroxytrytamine
N-Acetyl-5-hydroxytryptamine
N-Acetylserotonin
5-Hydroxymelatonin
5-Hydroxy-N-acetyltryptamine
Normelatoni
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]ethanamide
N-Acetyl-5-hydroxytryptamine, 3-(N-Acetyl-2-aminoethyl)-5-hydroxyindole, 98%
N-Acetylserotonin, Normelatonin
物理化学性质
| 熔点 | 120-122 °C(lit.) |
| 沸点 | 556.8±40.0 °C(Predicted) |
| 密度 | 1.268±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | ethanol: 50 mg/mL |
| 酸度系数(pKa) | 10.09±0.40(Predicted) |
| 形态 | powder |
| 颜色 | white |
| 稳定性 | 吸湿性 |
| CAS 数据库 | 1210-83-9(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H319-H302-H335-H315 |
| 防范说明 | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| 安全说明 | S22-S24/25 |
| WGK Germany | 3 |
| 海关编码 | 29339900 |
图谱信息
N-乙酰-5-羟色胺(1210-83-9)质谱(MS)N-乙酰-5-羟色胺(1210-83-9)核磁图(1HNMR)N-乙酰-5-羟色胺(1210-83-9)核磁图(13CNMR)N-乙酰-5-羟色胺(1210-83-9)红外图谱(IR1)N-乙酰-5-羟色胺(1210-83-9)红外图谱(IR2)N-乙酰-5-羟色胺(1210-83-9)Raman光谱知名试剂公司产品信息
常见问题列表
| Target | Value |
|
TrkB receptor
() |
N-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner.
To explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation in vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF- and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect . These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation.