ChemicalBook CAS DataBase List 979-88-4

979-88-4

Name	2,2'-Biquinoline-4,4-dicarboxylic acid disodium salt
CAS	979-88-4
EINECS(EC#)	629-761-2
Molecular Formula	C20H11N2Na2O4
MDL Number	MFCD00037500
Molecular Weight	389.29
MOL File	979-88-4.mol

Synonyms

2,2'-BICINCHONINIC ACID DISODIUM SALT 2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DISODIUM SALT 2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DISODIUM SALT TRIHYDRATE 4,4'-DICARBOXY-2,2'-BIQUINOLINE DISODIUM SALT 4,4'-DICARBOXY-2,2'-BIQUINOLINE, SODIUM SALT BCA BCA DISODIUM SALT BICINCHONINIC ACID DISODIUM SALT BICINCHONINIC ACID DISODIUM SALT HYDRATE DI-SODIUM 2,2'-BICINCHONINATE DISODIUM 2,2'-BIQUINOLINE-4,4'-DICARBOXYLATE SODIUM BICINCHONINATE,4,4'-DICARBOXY-2,2'-BIQUINOLINE 2,2’-biquinoline-4,4’-dicarboxylicaciddisodiumsalt2h2o SodiumBicinchoniate SodiumBicinchoninate 2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DISODIUM SALT 2-HYDRATE 4 4''-DICARBOXY-2 2''-BIQUINOLINE DISODIUM BCA 4,4'-Dicarboxy-2,2'-biquinoline disodium salt>98% Bicinchoninic acid disodium salt, BCA disodium salt 4,4μ-Dicarboxy-2,2μ-biquinoline disodium salt, BCA, Disodium 2,2μ-biquinoline-4,4μ-dicarboxylate, 2,2μ-Biquinoline-4,4μ-dicarboxylic acid disodium salt

Chemical Properties

Melting point	300℃
storage temp.	Inert atmosphere,2-8°C
solubility	0.5% sodium bicarbonate: soluble50mg/mL
form	Powder/Chunks
color	white to light yellow
Water Solubility	Soluble in water.
Detection Methods	HPLC
Stability:	Hygrscopic
Major Application	diagnostic assay manufacturing hematology histology
InChI	InChI=1S/C20H12N2O4.Na.H/c23-19(24)13-9-17(21-15-7-3-1-5-11(13)15)18-10-14(20(25)26)12-6-2-4-8-16(12)22-18;;/h1-10H,(H,23,24)(H,25,26);;
InChIKey	AUPXFICLXPLHBB-UHFFFAOYSA-L
SMILES	C(C1=CC(C2=NC3=CC=CC=C3C(C(=O)O)=C2)=NC2=CC=CC=C12)(=O)O.[NaH]
CAS DataBase Reference	979-88-4(CAS DataBase Reference)
EPA Substance Registry System	979-88-4(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes	Xn,Xi
Risk Statements	R36/37:Irritating to eyes and respiratory system . R42:May cause sensitization by inhalation. R36/38:Irritating to eyes and skin . R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S22:Do not breathe dust . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37:Wear suitable protective clothing and gloves . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36:Wear suitable protective clothing . less more
WGK Germany	3
TSCA	Yes
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2

Hazard Information

Description

2,2’-Biquinoline-4,4’-dicarboxylic acid (BCA) is a colorimetric reagent for the detection of copper (Cu⁺). BCA and Cu⁺ form a stable 2:1 complex that has an absorbance maximum at 562 nm. It is commonly used as a reagent in the colorimetric BCA protein quantitation assay in which Cu²⁺ is converted to Cu⁺ as a function of protein concentration under alkaline conditions.

Chemical Properties

White to light yellow powder

Uses

For determination of Cu and protein assays.Bicinchoninic acid disodium salt is useful for the determination of copper. It is also used for the determination of protein concentration.

Application

2,2'-Bicinchoninic Acid Disodium Salt is a photometric reagent for protein assay. It is used for determination of reducing sugar and protein via Cu(I). Also a specific reagent for Cu(I) with sensitivity similar to that of neocuproin.

Biochem/physiol Actions

Bicinchoninic acid is used for the determination of protein concentration. It is responsible for the making of intense purple complex with cuprous ion (Cu+), in presence of alkaline conditions. The amount of Cu+ is in relation with the protein concentration.

References

[1] P.K. SMITH. Measurement of protein using bicinchoninic acid[J]. Analytical biochemistry, 1985, 150 1: Pages 76-85. DOI: 10.1016/0003-2697(85)90442-7
[2] BRENNER A.J. Harris E D. A Quantitative Test for Copper Using Bicinchoninic Acid[J]. Analytical biochemistry, 1995, 226 1: Pages 80-84. DOI: 10.1006/abio.1995.1194
[3] WALKER J M. The bicinchoninic acid (BCA) assay for protein quantitation.[J]. Methods in molecular biology, 1994, 32: 5-8. DOI: 10.1385/0-89603-268-x:5

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