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2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid (EDOTacid) serves as a comonomer with 3,4-ethylenedioxythiophene (EDOT) or its derivatives to introduce controlled hydrophilicity into the resulting copolymers[1]. This compound functions as a monomer for electropolymerization and general polymerization processes to synthesize thiophene-based polymers and copolymers[2][3].

2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid can be prepared from thioglycolic acid as a starting material in seven steps.

[1] Vivek Subramanian. (2019). Morphology, Molecular Orientation, and Solid-State Characterization of 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic Acid (EDOTacid). Crystal Growth & Design, 19 11, 6184–6191. https://doi.org/10.1021/acs.cgd.9b00613
[2] Dr. Thierry Darmanin, Prof. F. G. (2013). pH- and Voltage-Switchable Superhydrophobic Surfaces by Electro-Copolymerization of EDOT Derivatives Containing Carboxylic Acids and Long Alkyl Chains. Chemphyschem, 14 11, 2529–2533. https://doi.org/10.1002/cphc.201300283
[3] Alexander Shaver, & Netzahualcóyotl Arroyo-Currás*, (2023). Survey of Conductive Polymers for the Fabrication of Conformation Switching Nucleic Acid-Based Electrochemical Biosensors. ACS Applied Polymer Materials, 6 1, 541–551. https://doi.org/10.1021/acsapm.3c02206