General Description
White to yellow needle-like crystalline solid with a sweetish odor.
Reactivity Profile
4-NITROBIPHENYL(92-93-3) is incompatible with the following: Strong reducers .
Air & Water Reactions
Insoluble in water.
Hazard
Toxic by ingestion and skin contact. Confirmed carcinogen.
Potential Exposure
4-Nitrobiphenyl was formerly used in
the synthesis of 4-aminodiphenyl. It is presently used only
for research purposes; there are no commercial uses.
First aid
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration
with the aid of a pocket mask equipped with a one-way valve
or other proper respiratory medical device. Administer oxygen
if breathing is difficult. Remove and isolate contaminated
clothing and shoes. In case of contact with substance, immediately
flush skin or eyes with running water for at least
20 minutes. For minor skin contact, avoid spreading material
on unaffected skin. Keep victim warm and quiet. Effects of
exposure (inhalation, ingestion or skin contact) to substance
may be delayed. Ensure that medical personnel are aware of
the material(s) involved and take precautions to protect themselves.
Medical observation is recommended for 24 48 hours
after breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or authorized
paramedic may consider administering a drug or other
inhalation therapy.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
Incompatibilities
Incompatible with strong reducing agents
such as hydrides, oxidizers (chlorates, nitrates, peroxides,
permanganates, perchlorates, chlorine, bromine, fluorine,
etc.); contact may cause fires or explosions. Keep away
from alkaline materials, strong bases, strong acids, oxoacids,
epoxides.
Chemical Properties
4-Nitrobiphenyl exists as yellow plates or needles..
Chemical Properties
Yellow Solid
Waste Disposal
Incineration @ 982℃/2.0 seconds
(minimum) with scrubbing for nitrogen oxides
abatement.
Uses
4-Nitrobiphenyl has some uses as a plasticizer, fungicide, and
wood preservative.
Uses
Formerly in preparation of p-biphenylamine, q.v.
Uses
Formerly used as an intermediate for
4-aminobiphenyl
Definition
ChEBI: 4-Nitrobiphenyl is a member of biphenyls.
Health Hazard
p-Nitrobiphenyl (PNB) is a
urinary bladder carcinogen in dogs.
Toxicology
4-Nitrobiphenyl is no longer manufactured or used in the United States. Limited information is available on the health effects of 4-nitrobiphenyl. Acute (short-term) exposure to 4-nitrobiphenyl in humans results in irritation of the eyes, mucous membranes, and respiratory tract, such as headache, nausea, vomiting, and fatigue. Chronic (long-term) exposure to high concentrations of 4-nitrobiphenyl in workers has resulted in effects on the peripheral and central nervous systems as well as the liver and kidney. No information on the reproductive, developmental, or carcinogenic effects of 4-nitrobiphenyl in humans is available. EPA has not classified 4-nitrobiphenyl for carcinogenicity. 4-Nitrobiphenyl is no longer manufactured, imported, used, or sold in the United States.
Carcinogenicity
The case for the carcinogenicity of PNB
is supported by (1) the induction of urinary
bladder cancer in dogs after administration of
PNB; (2) the evidence that PNB is metabolized
in vivo to 4-aminobiphenyl (a potent carcinogen);
and (3) the possibility that the cases of
human urinary bladder cancer attributed to 4-
aminobiphenyl may also have been induced by
exposure to PNB.1
