Phosphomannose isomerase is the first enzyme involved in the biosynthesis pathway of GDP-Man. Phosphomannose isomerase catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P). Phosphomannose isomerase is important for cell wall synthesis and protein glycosylation. Phosphomannose isomerase is a potent antifungal target to curb the threats posed by A. flavus[1].
References
[1] Usman S, et al. Phosphomannose Isomerase Is Involved in Development, Stress Responses, and Pathogenicity of Aspergillus flavus. Microbiol Spectr. 2022 Oct 26;10(5):e0202722. DOI:10.1128/spectrum.02027-22
