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Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma[1][2].

MMP-2: 988.9 nM (Ki); MMP-9: 1.76 μM (Ki)

[1] Yuying Zhang, et al. Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells. Drug Des Devel Ther. 2019 Jul 29;13:2591-2601. DOI:10.2147/DDDT.S180610
[2] Mohammad Al-Amin, et al. Inhibitory Effect of Dioscorea bulbifera Tubers on the Migration of Triple-Negative Breast Cancer Cells. Breast Cancer Cells. Rev. Bras. Farmacogn. 31, 335–341 (2021).