813-94-5

Name	Calcium citrate
CAS	813-94-5
EINECS(EC#)	212-391-7
Molecular Formula	C12H10Ca3O14
MDL Number	MFCD00078618
Molecular Weight	498.43
MOL File	813-94-5.mol

Chemical Properties

Appearance	white powder or white to colourless crystals
solubility	0.1 M HCl: 0.01 M at 20 °C, clear, colorless
Odor	at 100.00?%. odorless
Stability:	Stable. Incompatible with strong oxidizing agents.
LogP	-1.721 (est)
CAS DataBase Reference	813-94-5(CAS DataBase Reference)
EPA Substance Registry System	Tricalcium citrate (813-94-5)

Safety Data

WGK Germany	1
Hazardous Substances Data	813-94-5(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

Chemical Properties

white powder or white to colourless crystals

Definition

ChEBI: Calcium citrate is an organic calcium salt composed of calcium cations and citrate anions in a 3:2 ratio. It has a role as a nutraceutical, a food additive, a food preservative and a flavouring agent. It contains a citrate(3-).

Production Methods

Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.

Flammability and Explosibility

Nonflammable

Pharmaceutical Applications

Calcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24% Ca²⁺, which means that 1000 mg calcium citrate contains around 240 mg Ca²⁺. The lower Ca²⁺ content together with the higher price makes it a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this.

Biological Activity

In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.

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813-94-5

Chemical Properties

Safety Data

Raw materials And Preparation Products

Raw materials

Hazard Information

Chemical Properties

Definition

Production Methods

Flammability and Explosibility

Pharmaceutical Applications

Biological Activity

Questions And Answer

Description

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Well-known Reagent Company Product Information

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