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• Pharmacological action

  Venakaran works by blocking peak sodium currents by blocking overdrive-activated delayed rectifier currents (IKur). IKur, encoded by the Kv1.5 channel protein, is abundantly expressed in atrial myocytes, is the main current mediating atrial repolarization in humans, and is activated during atrial fibrillation. Venakalan inhibition of IKur can prolong the action potential duration of the atrium, thereby prolonging the atrial effective refractory period and slowing down atrial conduction, so as to shorten the time of atrial fibrillation and quickly achieve the effect of atrial fibrillation conversion.;

• Application

  Venakalan is a mixed sodium/potassium channel blocker that selectively acts on atrial ion channels. It is more effective than amiodarone in the acute conversion of newly diagnosed atrial fibrillation and is used clinically to treat atrial fibrillation.;

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