Potential Exposure
Fluazifop-butyl is a selective post emergence aryloxyphenoxypropionate/organofluorine herbi cide. Its principal uses In California is on rights-of-way,
landscapes, almonds, cotton, and outdoor container
nurseries.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions) if
breathing has stopped, and CPR if heart action has stopped.
Transfer promptly to a medical facility. When this chemical
has been swallowed, get medical attention. Do not induce
vomiting when formulations containing petroleum solvents
are ingested. Otherwise, give large quantities of water and
induce vomiting. Do not make an unconscious person
vomit.
Description
Fluazifop-P-butyl is a post-emergence herbicide used to control grass weeds in a range of cropping situations. It has a low aqueous solubility, miscible in many organic solvents and is not considered to be volatile. It is not expected to be persistent in either soil or water-sediment systems. It is unlikely to leach to groundwater. Toxicity to biodiversity is low to moderate. Fluazifop-P-butyl also has a low oral mammalian toxicity.
Chemical Properties
light yellow liquid
Chemical Properties
Pale yellow liquid. Odorless.
Waste Disposal
In accordance with
40CFR165, follow recommendations for the disposal of
pesticides and pesticide containers. Containers must be dis posed of properly by following package label directions or
by contacting your local or federal environmental control
agency, or by contacting your regional EPA office.
Uses
Fluazifop-P-butyl may be used as a reference standard for the determination of the analyte:
- In different varieties of lettuce (Lactuca sativum) by capillary gas chromatography with nitrogen–phosphorus detection (NPD).
- In tea samples by modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample preparation procedure combined with ultra-performance liquid chromatography-electrospray tandem mass spectrometry (UPLC/MS/MS).
', 'Refer to the productμs Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Definition
ChEBI: A butyl 2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoate that has R configutation. The active enantiomer of the herbicide fluazifop-butyl, it is used as a post-emergence herbicide for the control grass weeds in various broad-l
aved crops.
Production Methods
The commercial production of fluazifop-P-butyl involves a stereoselective synthesis to isolate the herbicidally active R-enantiomer of fluazifop-butyl. The process begins with the preparation of a substituted pyridyl ether intermediate, typically involving the reaction of 5-(trifluoromethyl)-2-pyridinol with a halogenated phenol to form the aryloxyphenoxy core. This intermediate is then coupled with (R)-2-chloropropionic acid or its derivatives under controlled conditions to ensure retention of stereochemistry. The resulting acid is esterified with butanol to produce the butyl ester form, fluazifop-P-butyl. Purification steps such as crystallisation or chromatography are used to isolate the pure R-isomer, which is then formulated.
Mechanism of action
Selective, absorbed through leaf surface. Acetyl CoA carboxylase inhibitor (ACCase) - distrupts fatty acid biosynthesis and lipid formation.
