779282-36-9

AP39 is a compound used to increase the levels of hydrogen sulfide (H₂S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H₂S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H₂S-releasing portion.

AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.[Cayman Chemical]

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[1] BARTOSZ SZCZESNY . AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro[J]. Nitric oxide?: biology and chemistry, 2014, 41: Pages 120-130. DOI: 10.1016/j.niox.2014.04.008