ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H
2S) donor. It can be readily esterified with other moieties.
1 For example, it can be coupled with therapeutics like nonsteroidal anti-inflammatory drugs, as in the generation of ATB-343 (Item No.
13045).
2 ADT-OH has also been linked with a mitochondria-targeting motif to produce AP-39 (Item No.
17100), which selectively increases mitochondrial H
2S levels.
3 ADT-OH is used both in cells and in animals for comparative studies with derived chimeras.
3,4