76939-46-3

Off-white powder

Cell-permeable cAMP analog; activator of protein kinase A. Also available as part of the PKA Tocriset™ .

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

-20°C (desiccate)

[1]ulloa-aguirre a,?august am,?etal. , 8-bromo-adenosine?3',5'-monophosphate?regulates?expression?of?chorionic?gonadotropin?and fibronectin in human cytotrophoblasts. j clin endocrinol metab.?1987 may;64(5):1002-9.
[2] rene e m. y. barge, j.h. frederik falkenburg, etal., 8-bromo-camp induces a proliferative response in an il-3 dependent leukemic cell line and activates erk1,2 via a shc-independent pathway. biochimica et biophysica acta 1355 (1997) 141–146.
[3] haycock jw, bennett wf, etal. , multiple site phosphorylation of tyrosine hydroxylase. differential regulation in situ by a 8-bromo-camp and acetylcholine. j biol chem. 1982 nov 25;257(22):13699-703.