768-90-1

WHITE TO ALMOST WHITE CRYSTALS OR CRYST. POWDER

1-Bromoadamantane shows some anti-viral activity due to the adamantane structure. In addition it shows anti-microbial activity and cytotoxic application.

use: Amantadine, Rimantadine, Somantadine, Tromantadine

1-Bromoadamantane was used in the synthesis of a new organic–organic nanoscale composite thin-film dielectric.
1-Bromoadamantane forms inclusion complexes with α-, β-, and γ-cyclodextrins. It causes the alkylation of Co(II) complexes of β-diketones.

The Journal of Organic Chemistry, 45, p. 5239, 1980 DOI: 10.1021/jo01314a003

If coloured, dissolve it in CCl4, wash with H2O, treat with charcoal, dry (CaCl2), filter and evaporate to dryness. Dissolve the residue in a small volume of MeOH and cool in a CO2/trichloroethylene bath and collect the crystals. Sublime it at 90-100o/water pump vacuum. [Stetter et al. Chem Ber 92 1629 1959, Schleyer & Nicholas J Am Chem Soc 83 2700 1961, Beilstein 5 III 469.]