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Tephrosin as a natural rotenoid obtained from Tephrosia vogelii and displays anticancer activity.

ChEBI: A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a a d methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.

Tephrosin is a plant-based rotenoid which has known anti-cancer properties. Tephrosin inhibited proliferation in A549 cancer cells in a dose-sependent manner. Tephrosin has been shown to induce capase-independent apoptosisand internalization and degradation of inactivated EGFR and ErB2 in human colon cancer cells.

ROS | PARP | Autophagy | HSP (e.g. HSP90) | EGFR | Akt | ERK | Caspase | AMPK | mTOR