Chemical Properties
Off-White Solid
Uses
Brassinolide can be used as plant growth regulator.
Uses
Plant growth regulator.
Definition
ChEBI: Brassinolide is a 2alpha-hydroxy steroid, a 3alpha-hydroxy steroid, a 22-hydroxy steroid, a 23-hydroxy steroid and a brassinosteroid. It has a role as a plant growth stimulator and a plant hormone.
General Description
Brassinolide is a plant growth hormone and the most biologically active brassinosteroid (BR). It has been implicated in Auxin signaling. It has also been used for studying plant biosynthetic pathways. Brassinolide might also regulate water-transport properties of cell membranes in Arabidopsis thaliana.
Biological Activity
brassinolide is a plant growth regulator. plant growth regulators are naturally produced by plants and are critical for regulating their own growth. plant growth regulators act via modifying or controlling plant growth processes, such as leave and flower formation, stem elongation, as well as fruit development and ripening.
Biochem/physiol Actions
Brassinolide is a plant growth hormone that has been implicated in Auxin signaling. It has also been used for studying plant biosynthetic pathways.
in vitro
brassinolide induced the time and concentration-dependent cytotoxicity in pc-3 cells. the mode of such cell death appeared to be apoptosis predominately, as demonstrated by fluorescence, flow-cytometric analyses and transmission electron microscopes. moreover, caspase-3 activity was increased after brassinolide treatment obviously. western blot studies showed brassinolide treatment triggered a time-dependent decrease in the expression of bcl-2 [1].
in vivo
brassinolide had the similar function of reducing the blood glucose levels as phenformin, but without the dose-dependent manner. the blood glucose levels showed significant differences after brassinolide treatment with different doses (200, 100, and 50 mg/kg). these results indicated that brassinolide could reduce the blood glucose levels without toxicity [2].
References
[1] wu yd,lou yj. brassinolide, a plant sterol from pollen of brassica napus l., induces apoptosis in human prostate cancer pc-3 cells. pharmazie.2007 may;62(5):392-5.
[2] chen shi-ping, he jia, wang qi-jing, wang jian-dong, ye yan-li, xian li-jian. effect of brassinolide on levels of blood glucose in alloxan—induced diabetes rats. acta metallurgica sinica, 2009,v26(03): 21-23
