224047-41-0

Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. Brassinazole, a triazole derivative, is an inhibitor of brassinosteroid biosynthesis that has been developed in order to probe the myriad functions of brassinosteroids. At 1 μM, it can induce morphological changes, including dwarfism and altered leaf color and curling, in dark-grown Arabidopsis and light-grown cress that are rescued by co-application of a brassinosteroid.

ChEBI: Brassinazole is a member of the class of triazoles that is butan-2-ol which is substituted at positions 2, 3, and 4 by phenyl, 1H-1,2,4-triazol-1-yl and p-chlorophenyl groups, respectively. An inhibitor of brassinosteroid biosynthesis. It has a role as a brassinosteroid biosynthesis inhibitor. It is a member of triazoles, a tertiary alcohol and a member of monochlorobenzenes.

This triazole-type inhibitor (FW = 327.81; CAS 224047-41-0; Brz2001), systematically named 4- (4-chlorophenyl) -2-phenyl-3-[[1,2,4]triazol-1- yl]butan-2-ol, targets brassinosteroid biosynthesis. The latter are plant steroids and phytohormones that promote organ growth through their combined effect on cell expansion and division, plant architecture, vascular differentiation, fertility and flowering, photo-morphogenesis, tolerance to biotic and abiotic stresses, as well as senescence. Brassinazole’s inhibitory action is reversed by brassinolide, which showed good recovery after addition brassinazole-treated plants. Although brassinazole is structurally similar to pacrobutrazol, a gibberellin biosynthesis inhibitor, it does not show any evidence of recovery upon addition of gibberellin. Brassinazole also induces morphological changes in dark-grown Arabidopsis.

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