72072-16-3

4-Butyl-2-methylaniline is used for the preparation of a number of substituted acetamides which are antagonists of MDR proteins for treatment of drug-resistant cancers.

SMIP004-7 is a cell penetrantpotent and selective ubiquinone uncompetitive inhibitor of mitochondrial Complex I (NADH:ubiquinone oxidoreductase). SMIP004-7 selectively binds to a distinct N-terminal region of Complex I catalytic subunit NDUFS2which leads to rapid disassembly of Complex I. SMIP004-7 potently inhibits growth of triple-negative breast cancer xenografts in mice.