684-16-2

HEXAFLUOROACETONE(684-16-2) is a colorless, toxic, and highly reactive gas. At ambient temperatures, HEXAFLUOROACETONE(684-16-2) is likely to generate a considerable amount of vapor. HEXAFLUOROACETONE(684-16-2) is an irritant to skin, eyes and mucous membranes and is toxic by ingestion, skin absorption, and inhalation. When heated to high temperatures HEXAFLUOROACETONE(684-16-2) emits toxic fluoride fumes. Prolonged exposure of the container to fire or intense heat may cause HEXAFLUOROACETONE(684-16-2) to violently rupture and rocket. HEXAFLUOROACETONE(684-16-2) is used in the production of other chemicals.

HEXAFLUOROACETONE is incompatible with the following: Water, acids [Note: Hygroscopic (i.e., absorbs moisture from the air); reacts with moisture to form a highly acidic sesquihydrate.] .

Hygroscopic (i.e., absorbs moisture from the air); reacts with moisture to form a highly acidic sesquihydrate. .

Toxic by inhalation and skin absorption. Reacts vigorously with water and other substances, releasing considerable heat. Nonflammable.

TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Vapors are extremely irritating and corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.

Hexafluoroacetone is used as a chemi cal intermediate. A gas at room temperature, it forms vari ous hydrates with water which are used as solvents for resins and polymers. Other derivatives are used to make water repellent coatings for textiles and also to produce polymers.

Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi cal attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy. If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, imme diately and thoroughly wash contaminated skin with soap and water.

UN2420 Hexafluoroacetone, Hazard Class: 2.3; Labels: 2.3-Poisonous gas, 8-Corrosive material, Inhalation Hazard Zone B. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the com pressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylin ders without the express written permission of the owner.

Reacts with water, oxidizers, strong acids. Hygroscopic (i.e., absorbs moisture from the air); reacts with moisture to form a highly acidic sesquihydrate and considerable heat.

Hexafluoroacetone is a colorless, nonflammablepoison gas. Musty odor. Shipped as a liquefied compressedgas. .Molecular weight= 163.00; Boiling point =- 28to - 26℃; FreezingMelting point= - 122℃; Relative vapordensity (air= 1)= 5.76; Vapor pressure = 5.8 atm at 25℃.Hazard Identification (based on NFPA-704 M Rating System):Health 3, Flammability 0, Reactivity 0. Reacts with water.

generally supplied as liquid under pressure

Hexafluoroacetone is a colorless, nonflamma ble poison gas. Musty odor. Shipped as a liquefied com pressed gas.

Return refillable compressed gas cylinders to supplier. Nonrefillable cylinders should be disposed of in accordance with local, state and federal regulations. Allow remaining gas to vent slowly into atmosphere in an unconfined area or exhaust hood. Refillable-type cylinders should be returned to original sup plier with any valve caps and outlet plugs secured and valve protection caps in place.

Hexafluoroacetone is a protecting and activatng reagent used in the synthesis of (S)-isoserine from (S)-malic acid. It is also an intermediate used to prepare hexafluorocarbinols as liver X receptor-α agonists.

In the synthesis of polymer, pharmaceutical, and agricultural chemicals; solvent for polyamides, polyesters, and polyacetals; in the synthesis of hexafluoroisopropanol

Protecting and activating reagent in peptide chemistry; in synthesis of high performance fluoropolymers, pharmaceutical and agricultural chemicals; in 19F NMR. Solvent for polyamides, polyesters, polyacetals, polyols.

ChEBI: A ketone that is acetone in which all the methyl hydrogens are replaced by fluoro groups.

Canadian Journal of Chemistry, 33, p. 453, 1955 DOI: 10.1139/v55-055
Organic Syntheses, Coll. Vol. 7, p. 251, 1990

(1) Color Code- White stripe: Contact Hazard;Store separately; not compatible with materials in solidwhite category. (2) Color Code- Blue (poison gas): HealthHazard/Poison: Store in a secure poison location. Prior toworking with this chemical youshould be trained on itsproper handling and storage. Store in tightly closed contain-ers in a cool, well-ventilatedarea away from direct sunlight,water，heat, reducing agents， nitrates, and nitric acid.Procedures for the handling, use, and storage of cylindersshould be in compliance with OSHA 1910.101and1910.169, as with the recommendations of the CompressedGas A ssociation.

Dehydrate hexafluoroacetone by passing the vapours over P2O5. Ethylene is removed by passing the dried vapours through a tube containing Pyrex glass wool moistened with conc H2SO4. Further purification is by low temperature distillation using Warde-Le Roy stills. Store it in the dark at -78o. [Holmes & Kutschke Trans Faraday Soc 58 333 1962, Beilstein 1 IV 3215.]