6817-41-0

Tomita and his co-workers have obtained this bisisoquinoline alkaloid from the embryo of the seeds of Nelumbo nucifera Gaertn. The base has [α]²⁹_D + 49.3° (Me2CO) and - 43.3° (CHC13 ). The hydrochloride tetrahydrate forms colourless crystals, m.p. l85-6°C (dry); the perchlorate monohydrate has m.p. 200-3°C (dry); [α]²²_D - 70° (Me2CO) and the styphnate of the O,O-dimethyl ether, also crystalline, has m.p. l33-5°C; [α]²⁷_D - 81.5° (Me2CO). Three methoxyl, two hydroxyl and two methylimino groups are present.

(+)-Isoliensinine is an alkaloid which displays activation of AMP-activated kinase and regulation of PPARγ receptors.

ChEBI: Isoliensinine is a member of isoquinolines.

Tomita et aI., Tetrahedron Lett., 2637,3374 (1964)