ChemicalBook CAS DataBase List 5041-81-6

5041-81-6

Name	ISOLIQUIRITIN
CAS	5041-81-6
EINECS(EC#)	1308068-626-2
Molecular Formula	C21H22O9
MDL Number	MFCD00272145
Molecular Weight	418.39
MOL File	5041-81-6.mol

Chemical Properties

Melting point	185-186℃
Boiling point	743.5±60.0 °C(Predicted)
density	1.528
storage temp.	4°C, protect from light
solubility	Soluble in methan
form	powder
pka	7.46±0.35(Predicted)
color	Ochre
biological source	plant
InChI	InChI=1/C21H22O9/c22-10-17-18(26)19(27)20(28)21(30-17)29-13-5-1-11(2-6-13)3-8-15(24)14-7-4-12(23)9-16(14)25/h1-9,17-23,25-28H,10H2/b8-3+/t17-,18-,19+,20-,21-/s3
InChIKey	YNWXJFQOCHMPCK-RQOZFYCLNA-N
SMILES	[C@@H]1([C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)OC1=CC=C(/C=C/C(=O)C2C=CC(O)=CC=2O)C=C1 \|&1:0,1,3,4,6,r\|

Hazard Information

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from licorice.

Uses

It is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Definition

ChEBI: A monosaccharide derivative that is trans-chalcone substituted by hydroxy groups at positions 2' and 4' and a beta-D-glucopyranosyloxy group at position 4 respectively.

Biological Activity

Isoliquiritin triggers apoptotic cell death by increasing the levels of p53 and p21 in A549 non-small cell lung cancer cells while also inhibiting the p53-dependent pathway and revealing interactions with Akt activities. FutherIsoliquiritin has demonstrated neuroprotective activity against oxidative stress and has the capability to restrain the growth of microbial pathogens.

in vivo

Isoliquiritin (0.31-3.1 mg/kg, i.p., once a day for 5 days) inhibits granuloma angiogenesis in mice^[1].
Isoliquiritin (10-40 mg/kg, oral gavage) shows antidepressant-like effects in FST and TST tests in mice^[2].
Isoliquiritin ((10 mg/kg/bw/day, p.o.) shows anti-oxidative and anti-Inflammatory properties, and relieves cationic BSA-Induced membranous glomerulonephritis in experimental rat model^[5].

Animal Model:	Mice in Forced Swimming Test (FST) and the Tail Suspension Test (TST)^[2]
Dosage:	10, 20 and 40 mg/kg
Administration:	oral gavage
Result:	Reduced the immobility time in the FST and TST in mice. Increased 5-HT and NE level and Reduced the ratio of 5-HIAA/5-HT in the hippocampus, hypothalamus and cortex.

target

HIV

storage

4°C, protect from light

Spectrum Detail

Supplier

Chembest Research Laboratories Limited

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TargetMol Chemicals Inc.

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Cheng Du Pufeide Biotechnology Co., Ltd.

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