6730-83-2

Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties. It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC₅₀ values ranging from 15.03 to 48.87 μg/ml. Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml). Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from plants such as Acanthopanax Cortex (1% content) and Bletilla striata leaves.

ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma.

ChEBI: An ent-kaurane diterpenoid that is ent-kauran-19-oic acid in which a double bond is present at position 16(17); exhibits anticancer and anti-HIV 1 activity.

[1] L.A.F. PAIVA . Anti-inflammatory effect of kaurenoic acid, a diterpene from Copaifera langsdorffii on acetic acid-induced colitis in rats[J]. Vascular pharmacology, 2002, 39 6: Pages 303-307. DOI: 10.1016/s1537-1891(03)00028-4
[2] GENEIVE E. HENRY . Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro[J]. Cancer letters, 2006, 244 2: Pages 190-194. DOI: 10.1016/j.canlet.2005.12.022
[3] A. C. F. SOARES. Variability of the antibacterial potential among analogue diterpenes against Gram-positive bacteria: considerations on the structure–activity relationship[J]. Canadian Journal of Chemistry, 2019, 62 1. DOI: 10.1139/cjc-2018-0369