34348-59-9

ChEBI: Isoegomaketone is an aromatic ketone.

Synthesis, p. 991, 1984 DOI: 10.1055/s-1984-31051

This compound tested in in vivo models of B16 melanoma gave a significant cellgrowth inhibition. The tumor cells show an ROS-mediated mitochondria-dependentapoptotic-type death in sub-G1 cell cycle. Iso-egomaketone seemed to generateROS in cells as well as upregulation of Bax and Bcl-2expression (Russo et al. 2015;Shen et al. 2012).