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Example I Large-scale reaction of paclitaxel with NaHCO3: 500 mg (0.57 mmol) of paclitaxel was dissolved in 10 mL of THF and transferred to a 25 mL round-bottom flask equipped with a magnetic stirrer. To this solution, 10 mL of 30% H2O2 and 960.0 mg of NaHCO3 were sequentially added and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, extraction was carried out using dichloromethane/water (50:50 v/v). The organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product, which was further purified to obtain 457.2 mg 10-deacetylpaclitaxel in 96% yield. The product was analyzed by NMR and mass spectrometry, and the data were consistent with known samples.